Cardior is an academic spin-off from Medical School Hannover (MHH). Founded in 2016, a Series A financing round of 15 mn. EUR was successfully closed in May 2017.

The company is focused on the development and clinical validation of noncoding (ncRNA) RNA therapeutics for patients with myocardial infarction and heart failure.

 

LATEST NEWS:

We are strengthening our team. Currently we are looking for:

Business Development Manager
Clinical Project Manager
Intellectual Property (IP) Manager
Research Scientist
Biological Laboratory Assistant / Technician (BTA) or MTA, CTA

For further details please refer to our career opportunities section.

Our Mission

Heart failure is a major contributor to the healthcare burden and mortality worldwide. A major reason for heart failure development is myocardial infarction (MI) that leads in about 20% of patients to early subsequent progressive structural remodeling of the heart resulting in early heart failure with poor prognosis. In most other cases MI leads to chronic heart failure also with a significantly reduced quality of life and reduced life span.

Current treatment options for patients with post-MI heart failure are surprisingly limited. With no new drugs on the market, post-MI heart failure and heart failure in general remains a deadly disease with no early curative treatment options. 

Our approach shall provide a novel class of therapeutics and a unique, revolutionary approach by modulating entire disease pathways to treating these diseases with high unmet medical need.

Management Team

CEO & CO-FOUNDER
CLAUDIA ULBRICH, MD
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CEO & CO-FOUNDER
CLAUDIA ULBRICH, MD

Dr. Claudia Ulbrich is an MD and health economist (ebs) by training with more than 20 years of expertise in the health care industry including managerial experience in stock listed biotech companies. She brings a broad range of experience in management and consulting and a strong network in venture capital, academia and industry, health economy, political and trade associations.

Claudia combines a high level of commercial competence with a sound knowledge of medical affairs and drug development along the valuation chain. With her proven ability in financing, deal closing and deep experience in strategy she is responsible for corporate development and investor relations.

Claudia is an integrative, experienced leader with proven success guiding international, cross functional teams. Claudia has worked in the pharmaceutical industry before she founded her first biotech company in 1998. She served as Cofounder and interim manager of several international biotech companies. Three years at PricewaterhouseCoopers as a Senior Advisor in Life Sciences were the backbone at the start of her own consulting business.

CSO & Founder
PROF THOMAS THUM, MD, PhD
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CSO & Founder
PROF THOMAS THUM, MD, PhD

Prof. Dr. Dr. med Thomas Thum is since 2009 the Director of the Institute of Molecular and Translational Therapeutic Strategies (IMTTS) at MHH, and since 2013 visiting Professor at the National Heart and Lung Institute at Imperial College London.

Thomas is a key opinion leader in the development of noncoding RNA-based therapeutic strategies in cardiovascular medicine and the author of over 250 scientific publications, appearing in leading journals e.g. Nature, additional Nature and Science publications as well as clinically orientated top journals such as Circulation or Lancet.

Thomas is also a member of the editorial boards of the world’s most important journals for cardiovascular research (e.g. Circulation Research and European Heart Journal). Furthermore, Thomas is a nucleus member of national and international research committees in the cardiovascular field, such as the European Society of Cardiology (ESC), the American Heart Association (AHA), and the International Society for Heart Research (ISHR). Thomas has received numerous awards for his work on non-coding RNAs in cardiovascular research. Thomas has filed over 20 patents, two of which have been successfully licensed pharma companies and are currently at phase II clinical development.

CMO
WILFRIED HAUKE, MD
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CMO
WILFRIED HAUKE, MD

Dr. Wilfried Hauke is a physician by training specialized in pharmaceutical medicine. With more than 30 years working in various fields of the pharmaceutical industry he gained outstanding experience in designing and leading clinical research studies, drug development and regulatory strategies. Wilfried exhibits a wide range of competences in management and consulting starting his career at Hoechst AG, Frankfurt and Roussel UCLAF, Paris where he was involved in the clinical development of antibiotics and cardiovascular drugs. More recently Wilfried took over responsibility as CMO for Trophos, Marseille and was key in medical matters of their assets, which were successfully acquired by Roche in 2015. As CMO and board member of a stock listed company, Wilfried adapted the lead compound development strategy and initiated change management processes. Throughout his career he successfully set focus in risk-benefit-analysis and completed due diligence projects supporting seller and purchaser perspective. He serves as Qualified Person for Pharmacovigilance for UK based pharma companies and supports as Medical Advisor orphan drug developments. Wilfried built up a strong network of research specialists as well as high ranking industrial partners and investors. Wilfried joined Cardior as CMO in early 2018.

Board

CLAUS KREMOSER, PhD, CHAIRMAN
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CLAUS KREMOSER, PhD, CHAIRMAN

Claus is cofounder and CEO of Phenex Pharmaceuticals AG, a drug discovery company in Heidelberg, Germany, since its inception in 2002. Phenex closed two highly valued deals (135 M licensing of RORg program to Janssen, 2012, and 470 M asset sale of FXR program to Gilead in 2014) placing it into the league of top performing biotech companies in Germany.

Claus has studied biochemistry in Tübingen and Munich and performed his PhD work in the lab of Friedrich Bonhoeffer at the Max-Planck Institute for Developmental Biology in Tübingen. He co-founded the Life Science group of EY in Germany in 1996 and became the main author of the first German EY biotechnology report in 1998. Between 1998 and 2002 Claus was VP Corporate Development at LION bioscience AG where he was instrumental in closing the 100 M Euro bioinformatics collaboration with Bayer as well as in LION´s 220 M Euro IPO in 2001.

Claus is elected member of the board at BIO Deutschland and board member at the US biotech companies Avelas, Fortis and TRx. Claus became chairman of the board at Cardior in late 2017.

JOACHIM ROTHE, PhD
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JOACHIM ROTHE, PhD

Joachim is Managing Partner at LSP, responsible for the German office in Munich. He has more than 20 years of VC experience in the US and Europe, and he was or is involved in a founding and/or director function in numerous deals including Idenix (sold to Merck&Co), Nouscom, Okairos (sold to GSK), Pharmasset (sold to Gilead) and U3 Pharma (sold to Daiichi-Sankyo).

Before joining LSP in 2002, JR held various positions at MPM Capital. Joachim also worked at McKinsey & Company and at Roche. He is a biochemist and molecular immunologist by training and he has authored numerous articles in leading scientific publications, including Nature.

ULRICH GRANZER, PhD
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ULRICH GRANZER, PhD

Ulrich is the founder and owner of Granzer Regulatory Consuting & Services and has more than 25 years of experience in drug development and regulatory affairs. He has held senior management positions at Glaxo as Director of Regulatory Affairs and was a member of Glaxo Wellcome's Global Regulatory Board.

Ulrich has broad experience in drug development including oligonucleotides. At BASF Pharma he served as Vice President of Global Regulatory Centres, assuming global responsibility for Regulatory Affairs, Drug Safety, and GXP in drug development. At Knoll he was responsible for the development of small molecules as well as several biological compounds in the indications of obesity, stroke, septic shock, and rheumatoid arthritis.

He was instrumental to the program for the first fully human anti TNF antibody, now marketed as Humira. Before starting his own consultancy in 2002, he joined Bayer as Vice President of Global Regulatory Affairs, whose responsibility extended over all regulatory aspects of development and submission projects worldwide."

MARKUS HOSANG, PhD
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MARKUS HOSANG, PhD

Markus is a General Partner and Managing Director at BioMedPartners in Basel, a  venture capital firm that manages the BioMedInvest family of funds. He obtained his PhD in Biochemistry from the ETH in Zurich and pursued his postgraduate training at Stanford University Medical School in neurobiology and subsequently at the University of Washington Medical School in Seattle.

He is currently on the board of directors of AlevaNeurotherapeutics, Anergis, Hookipa Biotech and Imevax, and was on the board of directors of SuppreMol, Okairos, GenKyoTex, Avontec and Neuraxo Pharmaceuticals. Prior to joining BioMedPartners, Markus was a venture partner at MPM Capital, where he managed their European office in Munich, was co-responsible for their European deal flow and served on the boards of several of their European portfolio companies including Omrix Pharmaceuticals, Kourion, IDEA and Atugen.

Before that Markus was at Roche in Basel for nearly 20 years, where he held several senior management positions of increasing importance in the Pharma R&D organisation. Among these were director and vice president of the global Pharma R&D strategy unit and a member of the board of Pharma R&D Directors for many years. In this virtue he was directly involved in several major strategic transactions of Roche.

Markus served on the board of directors and the board of trustees of the Swiss Foundation for Stipends in Medicine and Biology (SSMBS) as its treasurer during 1994-2002, and is currently the vice chairman of the board of directors of Unitectra AG, the combined technology transfer office of the universities of Zurich, Bern and Basel.  Markus has published numerous articles in peer-reviewed journals and holds several patents.

ILKA WICKE, PhD
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ILKA WICKE, PhD

In 2009 Ilka participated in the creation of the Boehringer Ingelheim Venture Fund as a strategic component of Boehringer Ingelheim to create an additional “window to external innovation“. Ilka joined the newly created Boehringer Ingelheim Venture Fund in 2010 as an investment manager and has since then been involved in several investments transactions of the fund. She serves as a board member for Promethera, Pcovery and Metabomed. 

Ilka has obtained her PhD in organic chemistry from the Johann Wolfgang Goethe University in Frankfurt. Following her graduation she spent a year as a postdoctoral fellow at the Sloan Kettering Cancer Center in New York investigating retroviral gene therapy approaches to stimulate antitumour responses.

She joined Boehringer Ingelheim in 1996 as head of an interdisciplinary research laboratory specializing in new drug discovery approaches. Thereafter, Ilka spent more than 13 years in the Corporate Licensing Division of Boehringer Ingelheim where she was responsible for the evaluation, negotiation and the management of several global licensing transactions.

MARTIN CROOK, PhD
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MARTIN CROOK, PhD

Martin serves as Global Lead Cardiovascular & Translational Medicine, Search & Evaluation, Business Development at Bristol-Myers Squibb. He leads global scouting and diligence activities for therapeutic opportunities in cardiovascular disease and pharmacodiagnostics across therapeutic areas including immuno-oncology. 

Previous to joining BMS, from 2005-2012 Martin led drug discovery teams at Merck Research Laboratories to discover and develop novel pharmaceutical therapies for the treatment of cardiovascular disease. In 2012, Martin joined Daiichi Sankyo to find business development opportunities in cardiometabolic disease and subsequently joined Bristol-Myers Squibb Business Development in 2015.

Martin received his B.Sc. Hons. from Lancaster University in 1995, a MSc in Immunology and Oncology from University of Birmingham in 1996 and his Ph.D., in cardiovascular disease, from the University of Bristol in 2000. Martin then went on to receive his postdoctoral training in Dr Elizabeth Nabel's Vascular Biology Branch of the National Heart Lung and Blood Institute (NIH) in Bethesda, Maryland.

PROF JOHANN BAUERSACHS, MD
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PROF JOHANN BAUERSACHS, MD

Professor Bauersachs acts as Head of the Department of Cardiology at Hannover Medical School (MHH). He studied Medicine at the University of Freiburg. After training as Clinical and Research Fellow at the Universities of Frankfurt and Heidelberg/Mannheim, in 1999 he moved to the University Hospital Wuerzburg where he became Consultant and Lecturer in Internal Medicine and Cardiology and was Associate Professor in the Department of Medicine from 2008 to 2010. Since 2010 Johann has been a full professor and director of the Department of Cardiology and Angiology at Hannover Medical School. 

Professor Bauersachs is Fellow and Board Member of the Heart Failure Association (HFA) of the ESC, Chair of the HFA Study Group on Peripartum Cardiomyopathy, and Past Chair of the Working Group on Myocardial Function. He is Chair of the Cardiovascular Section of the Fachkollegium Medizin,  Deutsche Forschungsgemeinschaft (DFG), Member of the Steering Committee of the DFG-funded  Cluster of Excellence REBIRTH, and Speaker of the Clinical Research Group (KFO) 311 “(Pre-)terminal heart and lung failure - mechanical unloading and repair” funded by the DFG. 

Professor Bauersachs is an interventional cardiologist with special interests in acute coronary syndromes, left ventricular healing and remodelling, acute and chronic heart failure, as well as intensive care. He is particularly interested in the pathophysiology and treatment of peripartum cardiomyopathy, in aldosterone and mineralocorticoid receptor-mediated mechanisms, and in the role of non-coding RNAs. He is Study Chair of the DIGIT-HF study investigating the effect of Digitoxin on morbidity/mortality in patients with advanced heart failure, and is extensively involved in many other clinical trials. He has indicated his willingness to serve as an advisor for clinical strategy

Scientific Advisory Board

ARTHUR A. LEVIN, PhD
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ARTHUR A. LEVIN, PhD

Arthur A. Levin, Ph.D. is Avidity Bioscience’s Executive Vice President of Research and Development. Dr. Levin has nearly 20 years of experience in the research and development of RNA-targeting therapeutics and 30 years of experience in the pharmaceutical industry. He has been involved in the development of more than 20 oligonucleotide therapeutics in clinical trials including both approved antisense drugs.

Prior to joining Avidity Dr. Levin ran Research and Development at miRagen Therapeutics and was Chief Development Officer at Santaris Pharma (Copenhagen) where he led the efforts on the first microRNA targeting therapeutic currently in Phase 2 clinical trials.  Before joining Santaris Pharma, Dr. Levin consulted for leading biotechnology and pharmaceutical companies, conducting research and development in RNA-based therapies such as mRNA, microRNA, and siRNA.

Prior to consulting, Dr. Levin was Senior Vice President of Development at Isis Pharmaceuticals, where he was responsible for the drug development of Isis’ products across a range of therapeutic areas. His expertise was instrumental in advancing more than a dozen oligonucleotide drugs from basic research to clinical development in areas such as neuromuscular diseases, infectious diseases, metabolic disorders, cardiovascular disease and cancer.

He joined Isis from Hoffmann-La Roche Inc. where he was Research Leader and made fundamental discoveries in retinoid therapeutics.  Dr. Levin holds a Ph.D. in Toxicology from the University of Rochester School of Medicine and Dentistry, New York and a B.S. in Biology from Muhlenberg College. He completed his post-doctoral work at the Chemical Industry Institute of Toxicology in Research Triangle, North Carolina. He the author of more than 70 papers and book chapters.

DAVID CRANDALL, PhD
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DAVID CRANDALL, PhD

David Crandall brings both scientific and executive R&D leadership experience from 30 years in the pharmaceutical industry.  Before joining the Scientific Advisory Board of Cardior Pharmaceuticals, Dr. Crandall held a leadership position at Johnson & Johnson, where he was responsible for the executive management of the heart failure portfolio, which included both small molecule and biopharma programs from preclinical discovery through early clinical development. 

He was instrumental in developing a hybrid research model blending internal expertise with external opportunities from academia and biotech to successfully advance programs into early clinical development.  As a component of this position, Dr. Crandall was a key corporate representative in discussions with potential partners and equity analysts.  Prior to joining Johnson & Johnson, Dr. Crandall held positions of increasing responsibility in pharmaceutical R&D at Bristol-Myers Squibb and Wyeth (Pfizer) Research. 

Dr. Crandall received his Ph.D. in Physiology from Iowa State University and was an NIH postdoctoral fellow in Endocrinology/Medicine at Emory University.  He is the author of numerous peer-reviewed scientific publications, book chapters and U.S. and foreign patents, and has served on the editorial boards of key journals in the field of drug discovery.

PROF DOUGLAS L. MANN, MD
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PROF DOUGLAS L. MANN, MD

Dr. Mann is the Lewin Chair and Professor of Medicine, Cell Biology and Physiology, Chief of the Division of Cardiology at the Washington University School of Medicine, and Cardiologist in Chief at Barnes Jewish Hospital in St. Louis. He received his medical degree from Temple University School of Medicine in Philadelphia and completed fellowships in clinical cardiology at the University of California San Diego, and Massachusetts General Hospital in Boston.

Dr. Mann's primary research interest has been the molecular and cellular basis of heart failure, with particular emphasis on the role of innate immunity in disease progression and recovery of the failing heart. The author of numerous peer reviewed articles on the role on inflammatory mediators in cardiac remodeling and myocardial recovery, Dr. Mann is also the editor of Heart Failure, A Companion to Braunwald’s Heart Disease, and a co-editor of Braunwald’s Heart Disease, the leading textbook in cardiovascular medicine. 

Dr. Mann is the founding editor for JACC: Basic to Translational Science, and is currently the on the Editorial Board for a number of leading cardiovascular journals. He is a member of the American Society for Clinical Investigation, the Association of American Physicians the Association of University Cardiologists, the Heart Failure Society of America and the American Clinical and Climatological Association. He is the past president of the Heart Failure Society. 

PROF FAIEZ ZANNAD, MD, PhD
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PROF FAIEZ ZANNAD, MD, PhD

Faiez Zannad, MD, PhD, FESC is Professor of Therapeutics at the University of Lorraine in Nancy, France. Cardiologist and heart failure specialist, PhD in clinical pharmacology (Oxford, UK). Head of the Division of Heart Failure and Hypertension and Director of the Inserm Clinical Investigation Center at “Institut Lorrain du Coeur et des Vaisseaux”, Nancy. 

Professor Zannad leads two EU FP7 granted programs: HOMAGE (omics biomarkers for mechanistic phenotyping and prediction of drug response) and FIBROTARGETS (fibrosis as a biotarget).

As the primary investigator or member of oversight committees in major clinical trials, he pioneered and/or made significant contributions to evidence-based heart failure therapy, mainly mineralocorticoid receptor antagonists (RALES, EPHESUS, EMPHASIS-HF), and beta-blockers (CIBIS) as well as in major comorbid diseases such as sleep disordered breathing (SERVE-HF), autonomic nervous dysfunction (NECTAR-HF, BEAT-HF), and diabetes (EXAMINE, EMPEROR), chronic kidney disease (FOSIDIAL, AURORA, ALCHEMIST), in diabetes (EXAMINE, EMPEROR), thrombosis in heart failure (COMMANDER-HF).

He served as Chairman of the French Society of Hypertension, Chairman of the ESC Working Group on pharmacology and drug therapy, and board member of the ESC Heart Failure Association. He is the founder and is currently organizing the Global CardioVascular Clinical Trialists (CVCT) Forum and Workshop, an annual international think tank gathering dedicated to the science of clinical trials, with meetings in Paris, Washington DC, Middle East and Asia.

As of 2016 Prof Zannad published more than 600 peer-reviewed papers. In 2014, he was awarded the European Society of Hypertension Paul Milliez Award and in 2017 the Lifetime Achievement Award from the ESC Heart Failure Association.

PROF SCOTT SOLOMON, MD
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PROF SCOTT SOLOMON, MD

Scott D. Solomon, MD is The Edward D. Frohlich Distinguished Chair, Professor of Medicine at Harvard Medical School, Director of Noninvasive Cardiology and Senior Physician at Brigham and Women’s Hospital. He directs the Cardiac Imaging Core Laboratory and the Clinical Trials Endpoints Center at Brigham and Women’s Hospital.

He received his A.B. from Williams College and his M.D. from Harvard Medical School. Dr. Solomon’s research interests have focused on changes in ventricular structure and function following myocardial injury, modifiers of risk and influences of outcome in patients following myocardial infarction and with chronic heart failure, cardiovascular safety of non-cardiovascular therapies, factors that influence the transition from hypertension to heart failure, and heart failure with preserved ejection fraction.

He has pioneered the use of cardiac imaging in cardiovascular drug and device development and use of imaging in clinical trials. He and his research group have played a leading role in many international clinical trials in heart failure, hypertension and myocardial infarction.

He led the NIH sponsored Celecoxib Cross-trials Safety Study which directly informed regulatory agencies about the safety of widely used non-steroidal anti-inflammatory agents. He directs the Cardiac Imaging Center for the NHLBI Atherosclerosis Risk in Communities (ARIC) study and Hispanic Community Health Study – Study of Latinos (HCHS-SOL), the two largest NIH cohort studies.

Dr. Solomon has recently studied the role for angiotensin receptor neprilysin inhibition in heart failure. Dr. Solomon leads a research group consisting of 10 faculty members, 8 research fellows and 40 support staff. He has directed the Harvard Medical School Cardiovascular Clerkship and the Echocardiography training program at Brigham and Women’s Hospital.

He has authored more than 400 peer-reviewed articles, reviews and editorials, two textbooks of cardiac imaging.. He is listed by Thomson-Reuters as one of the most highly cited scientists in the past 10 years. He is a Cardiology Section Editor at UpToDate and Internatonal Associate Editor at the European Heart Journal.

Technology

Noncoding RNA therapeutics

MicroRNAs are short pieces of noncoding RNA (ncRNA) native to all human cells that act as regulators of gene expression. In many diseases, their aberrant regulation can drive disease characteristics. Targeting microRNAs or long noncoding RNAs (lncRNAs) with synthetic complementary oligonucleotides allows correcting the aberrant pattern. This approach provides a novel class of therapeutics and a unique, revolutionary approach by modulating entire disease pathways to treating diseases with high unmet medical need.

See also our animated video on Youtube (Link).

Cardior’s core innovation, the patented and proprietary inhibiting compound is an oligonucleotide-based ncRNA inhibitor halting and reversing cardiac remodeling. It has several distinguishing features:

TARGET

synthetic ncRNA inhibitor that will reduce aberrant expression during maladaptive growth, restore cardiac function and thus normalize heart failure conditions.

DELIVERY

the compound is a highly stable water-soluble oligonucleotide that selectively blocks specific ncRNA in the heart by parenteral application.

APPLICATION

The current treatment stipulates a two-time treatment post-MI.

EVIDENCE

the compound proved long-term therapeutic efficacy and safety in a human-relevant post MI model in pigs, as well as in human cardiac tissues and cells, and is compatible with clinical drug regimes.

In addition Cardior has access to several follow-up candidates for development in heart failure therapy as well as has licensed a companion diagnostics approach to predict future outcome of MI patients. Finally, Cardior works on improved cardiac delivery technologies enabling safe longterm treatment of also chronic heart failure patients.

News

Cardior strengthens patent portfolio
Cardior strengthens patent portfolio of miRNAs for the diagnosis and therapy of heart and kidney diseases - Key patents acquired from Bayerische Patentallianz
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Hanover, Germany, November 1, 2018 - Cardior Pharmaceuticals GmbH, a company focused on the development of noncoding RNA (ncRNA) therapeutics for patients with myocardial infarction and heart failure, today announced it has acquired a portfolio of four microRNA (miRNA) patents from Bayerische Patentallianz GmbH (BayPAT). miRNAs are short pieces of ncRNA native to all human cells that act as regulators of gene expression. Cardior Pharmaceuticals has developed a novel class of ncRNA-based therapeutics modulating entire disease pathways to treat diseases with a high unmet medical need.

 

Among the inventors of the four acquired patents is Prof. Dr. med. Thomas Thum, co-founder and CSO of Cardior. The patents were filed while he was Research Group Leader at Julius-Maximilians-University, Wuerzburg (Germany). Financial terms were not disclosed. 

 

The acquired portfolio comprises three patents on the use of certain miRNAs for the diagnosis and treatment of heart diseases such as cardiac fibrosis and ischemia/ reperfusion injury and one patent covering a number of targets relevant for the diagnosis and treatment of ischemia/reperfusion injuries of the kidney. 

 

“We are delighted to expand our patent portfolio beyond heart diseases,” said Dr. Claudia Ulbrich, CEO of Cardior. “The transaction strengthens our position in cardiology and also enables us to move to further disease areas in the future.” 

 

She added that Cardior is preparing for the first clinical study of its lead candidate CDR, a synthetic antisense-oligonucleotide inhibitor of a molecular master-switch microRNA, which plays a crucial role in the development of heart failure. CDR aims to halt and reverse heart failure by acting on well-defined cellular pathways and is given by an easy route of administration. Cardior expects to initiate clinical studies in 2019. 

 

 

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About Cardior

 

Cardior Pharmaceuticals is a privately held German biopharmaceutical company pioneering the development of curative and preventive heart failure therapeutics based on non-coding RNA (ncRNA). Cardior’s therapeutic approach is using distinctive ncRNA signatures driving the molecular reprogramming that causes maladaptive remodeling and heart failure. Drug candidates developed by Cardior represent first-in-class ncRNA therapeutics and diagnostics for patients with myocardial infarction and heart failure. Founded in 2016 based on the work of cardiologist Prof. Dr. Thomas Thum of Hanover Medical School, the Company has raised EUR 15 Mio. from international investors LSP Life Sciences Partners, BioMedPartners, Boehringer Ingelheim Venture Fund (BIVF), Bristol-Myers Squibb (BMS) and High-Tech Gründerfonds (HTGF).

 

Contact Cardior

Claudia Ulbrich / Barbara Gaertner-Rupprecht

Cardior Pharmaceuticals GmbH
Feodor-Lynen-Str.15
30625 Hanover

Germany

Tel: +49 511 33 85 99 30

 

Media Inquiries

akampion

Dr. Ludger Wess / Ines-Regina Buth

Managing Partners

info@akampion.com

Tel. +49 40 88 16 59 64

Tel. +49 30 23 63 27 68

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Cardior has been selected as a participant in Euronext´s Techshare program
We are proud to announce that Cardior has been selected as a participant in Euronext´s Techshare program. read more

The capital markets training program for the first time includes non-listed German, Swiss, Italian and Spanish companies. Further information about Euronext Techshare can be found here:  https://tech.euronext.com/en/enternext-services/techshare

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Cardior strengthens IP position for its lead candidate against heart failure
Cardior executed a licence agreement between Medical School Hannover (MHH) providing the company with exclusive and comprehensive rights to its lead candidate against heart failure. read more

The licence further consolidates Cardior’s strong IP position in the field and highlights recent progress. The oligonucleotide-based compound targets certain regulatory microRNAs which play a crucial role in pathological restructuring processes in the heart that occur in about 20% of patients following a heart attack. In vivo studies have shown that the candidate, by inhibiting the target microRNAs, not only stops the fatal restructuring of the heart, but actually reverses it. This could represent a breakthrough for millions of patients. Based on recent results, Cardior is now accelerating the preparation of clinical trials.

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The Digital Female Leader Award
Successful women in the digital economy, hard to find? Here they are, the female founders and designers of companies, politics and society initiating, promoting and shaping digitization. read more

Claudia Ulbrich, Entrepreneur and CEO of Cardior Pharmaceuticals GmbH is one of them and we are delighted to announce her nomination as Digital Female Leader 2018 in the category science.
Take part in the online voting for the audience award here from August 1st-14th and vote for Claudia!
The Digital Female Leader Award #DFLA, an initiative of myself and Global Digital Women, outlines careers and motivations of successful women and role models from 11 categories. There will be three finalists in each category and the winner will be announced at the awards ceremony on December 1st, 2018.

 

Vote here: https://digital-female-leader.de

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Cardior at HTGF Family-Day 2018
The Family Day is the biggest of High-Tech Gründerfond‘s networking events and 2018’s version will take place on May 29th and 30th at Kameha Grand Hotel Bonn, Germany. read more

At this exclusive annual two-day conference in Bonn, Dr. Claudia Ulbrich (CEO) and Prof. Dr. Dr. Thomas Thum (CSO) will take advantage of the excellent opportunities to meet representatives and investors of more than 300 international venture capital companies.

The conference offers next to Start Up-exhibition and face-to-face-meetings various workshops e.g. on pricing innovation, SME instruments and new ESOP options where business angels and partners of the HTGF network refer to their experiences and investment criteria.

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Cardior will present latest developments at Bio€quity 2018
Dr. Claudia Ulbrich (CEO) will present Cardior’s latest developments in RNA-therapeutics for heart failure treatments at Bio€quity on May 15th, 2018. read more

During the 1:1 partnering event potential investors get the opportunity to learn more about the proprietary RNA technology revolutionizing heart failure treatment by targeting microRNAs.

Bio€quity Europe is the seminal industry event for financial dealmakers looking for investor-validated life science companies positioning themselves to attract capital, and for pharmaceutical licensing professionals to assess top prospects. Delegates from 24 nations attended Bio€quity Europe last year in Paris.

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LATEST PRESS CONTRIBUTIONS:
Please find below a compilation of the latest press references:
(click "read more") read more
Cardior Represented in the German Biotech Startup Report 2017
Cardior is now represented in the German Biotech Startup Report 2017. read more

Cardior’s core competences, lead compound and market potential are displayed together with further key data and statistics, so potential investors and pharma-partners get easy access to our company profile.

Link: https://reports.labiotech.eu/german-biotech-startup-2017-cardior/

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Dr. Wilfried Hauke
CARDIOR welcomes new CMO Dr. Wilfried Hauke
Dr. Wilfried Hauke joined CARDIOR as new Chief Medical Officer. read more

Wilfried is a physician by training specialized in pharmaceutical medicine. With more than 30 years of working in various fields of the pharmaceutical industry he gained outstanding experience in designing and leading clinical research studies, drug development and regulatory strategies.

Wilfried exhibits a wide range of competences in management and consulting starting his career at Hoechst AG, Frankfurt and Roussel UCLAF, Paris where he was involved in the clinical development of antibiotics and cardiovascular drugs. Using his unique combination of medical expertise and managerial experience he then served some international CROs as managing partner, CEO and CMO.

More recently Wilfried took over responsibility as CMO for Trophos, Marseille and was key in medical matters of their assets, which were successfully acquired by Roche in 2015. As CMO and board member of a stock listed company, Wilfried adapted the lead compound development strategy and initiated change management processes.  

Throughout his career he successfully set focus in risk-benefit-analysis and completed various due diligence projects supporting seller and purchaser perspective. He serves as Qualified Person for Pharmacovigilance for UK based mid-sized pharma companies and supports as Medical Advisor some orphan drug developments.

Wilfried built up a strong network of research specialists as well as high ranking industrial partners and investors. Additionally, he is longstanding member of the European Society of Cardiology, German Society of Internal Medicine, the German Society of Pharmaceutical Medicine, the Drug Information Association (DIA), Paul-Ehrlich Society of Chemotherapy (PEG) and the Faculty of Pharmaceutical Medicine at the Royal College of Physicians, London. Wilfried joined Cardior as CMO in early 2018.

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Althusmann congratulates Cardior at DurchSTARTer 2017
On December 4th the finalists of the Start Up Award “DurchSTARTer 2017” competed for the title of this year’s most outstanding Start Up in Lower Saxony. After pitching in front of a mixed audience Cardior was awarded third place. read more

Dr. Bernd Althusmann, Minister of economic affairs, congratulated Dr. Claudia Ulbrich and Prof. Dr. Dr. Thum on Cardior’s outstanding progress in the field of non-coding RNA therapies.

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Cardior welcomes new Chairman of the Board
In November 2017 Dr. Claus Kremoser was appointed as Chairman of Cardior’s Board of Directors. read more

Claus, Co-founder and CEO of Phenex Pharmaceuticals AG, is a highly skilled and longstanding expert in the Biotech- and Pharma-Industry sector. He brings along an extensive network of industrial partners and has a proven track record in deal making.

For more detailed information please refer to our board section.

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Cardior winner of Biofit Start up Slam 2017
We proudly announce that Cardior was awarded first place at this year´s Biofit Start up Slam in Strasbourg. read more

Out of 70 competitors and 20 final contestants the steering committee chose Cardior together with Vaxinano as the most innovative and promising start-ups in 2017. In a high paced 6 minutes pitch Dr. Claudia Ulbrich (CEO) and Prof. Dr. Dr. Thomas Thum (CSO) convinced the experts with staggering news on Cardior‘s business strategy and investment opportunities.

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Cardior elected for Start-up Slam at Biofit 2017
Next week Cardior will participate in the prestigious Start up Slam at Biofit 2017 in Strasbourg. A jury of experts elected Cardior as one of the most promising young Start up‘s to compete with 19 other entrepreneurs. read more

On November 28th, Dr. Claudia Ulbrich and Prof. Thomas Thum will pitch Cardior to a selection committee composed of high level representatives from international pharmaceutical and biotechnology industries, investors, technological transfer offices, biotechnology associations and public and private institutions. Based on their long lasting experience and knowledge, the panel of advisors will give feedback and offer advice to the selected applicants to support them developing their projects. Cardior will take part in Europe‘s leading partnering event to present its innovative non-coding RNA therapeutics and encounter future collaborators and partners.

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Press Release: Cardior Pharmaceuticals raises €15 million and appoints CEO and CSO
Hannover, Germany, May 11th 2017 – Cardior Pharmaceuticals, today announced the completion of a €15 million Series A financing round led by LSP (Life Sciences Partners), Boehringer Ingelheim Venture Fund (BIVF), Bristol-Myers Squibb (BMS), BioMedPartners (with its new BioMedInvest III Fund) and High-Tech Gründerfonds (HTGF). read more

Cardior is pioneering its proprietary RNA technology to revolutionize predicting and treating heart failure. The molecular targets are non-coding RNAs linked to heart failure development that simultaneously control cardiac growth and calcium handling / contractility of cardiomyocytes.

The targeting of certain specific non-coding RNAs reverses maladaptive cardiac remodeling and restores normal cardiac function.  “We are very excited to be leading this financing” said Dr. Joachim Rothe, Managing Partner at LSP and a director of Cardior. “There has been a painful lack of scientific and clinical progress in the cardiovascular field for the past 15 years, and Cardior is well positioned to change this.” In conjunction with this financing, Cardior appointed Dr. Claudia Ulbrich as Chief Executive Officer.

Claudia brings with her two decades of operational management and corporate development experience in pharma and biotech including publicly traded companies. “It is a rare opportunity to develop cutting-edge science in the area of cardiovascular diseases with a high unmet medical need. I am delighted to join Cardior at this exciting development stage of the company and together with its motivated team, quickly put on the map a novel class of drugs and companion diagnostics with the potential to prevent and overcome heart failure” said Dr. Claudia Ulbrich. “The significant funding raised at this stage of development of the company will provide the resources for an ambitious development plan for our lead compound,” added Prof Thomas Thum, who is joining the management team as Chief Scientific Officer. With a translational approach and multiple established academic collaborations, Cardior is uniquely positioned to apply innovative first-in-class therapy for myocardial infarction and heart failure patients.

Cardior is currently developing non-coding RNA based assets and companion diagnostics. Additionally, Cardior has access to a great variety of discovery programs of undisclosed targets of Prof. Thum’s pipeline.  About Cardior Pharmaceuticals: Cardior Pharmaceuticals is a privately held German biotech company pioneering the next generation of non-coding RNA based therapeutics in heart failure. Prof Thomas Thum and his team have built a globally renowned expertise in the non-coding RNA field and demonstrated previously their ability to develop & partner innovative drug candidates. The Medical School Hannover (MHH) and the Institute of Molecular and Translational Therapeutic Strategies (IMTTS) offer a favorable bench-to-bedside environment to support Cardior as one of the world ́s leading centers in RNA biology.

The intellectual property was licensed from Medical School Hannover (MHH), the Max-Planck- Society (MPG) and from several world renowned French Institutes.

Cardior is the winner of the Startup Challenge at Deutsche Biotechnologietage 2017, the largest German biotech summit. Founded in 2016 by Prof Thum, Cardior was initially supported by VentureVilla Inkubator, hannoverimpuls and Ascenion.

 

Contact:

Dr. Claudia Ulbrich, CEO, Cardior Pharmaceuticals claudia.ulbrich@cardior.de

+49 511 37484051

Prof. Dr. Dr. Thomas Thum, CSO, Cardior Pharmaceuticals

+49 511 532 5272

thomas.thum@cardior.de

Image Credit: Karin Kaiser/MHH

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Project leader Thomas Thum receives prestigious Outstanding Investigator Award
Project Leader Prof. Thomas Thum giving his Outstanding Investigator Award lecture at the 33rd Annual Meeting of the European Section of the International Society for Heart Research (ISHR) in Bordeaux. read more

Thomas was awarded the prestigious prize for his "research on non-coding RNAs in cardiovascular research and associated fields of research" that "provided new insight into the mode of action of various pathologies of the heart. He has developed major breakthroughs in both diagnostic and therapeutic approaches for cardiac diseases. Overall, his successful track record as a scientific investigator, translational scientist and Institute Director has established him as a leader in cardiovascular sciences."  Thomas joins Peter Carmeliet (2002), Issei Komuro (2003), Eric Olson (2005), Joseph Loscalzo (2006), Matthias Gautel (2009), Jeffery D. Molkentin (2010), Walter Koch (2011), Thomas Eschenhagen (2012), Deepak Srivastava (2013) and Asa Gustafsson (2014) in ISHR's Hall of Fame.

Further reading:  Press release    

 

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JOBS @ CARDIOR 

Cardior Pharmaceuticals GmbH is a research-based biotechnology company based in Hanover. The company's goal is to develop RNA-based innovative diagnostics and therapeutics for patients with heart failure. The first reference product will be an oligonucleotide-based microRNA inhibitor. 

Our current job vacancies are listed below.

send your application here

Business Development (BD) Manager

As Cardior’s BD manager you will design and implement a strategic business development plan and acquire and manage new relationships with international pharma/ biotech, academic and diagnostic partners. You will be responsible for conducting market researches, evaluating new IP and technological growth opportunities, negotiating licensing and other collaboration partnerships, developing commercial contractual documentation, actively support deal closing and providing professional support to the management. Become an expert on our proprietary RNA technology, lead compound and state of the art companion diagnostic approaches.

 

Employment type       

  • Permanent
  • Full or part-time 50-100%  

Duties and Responsibilities

 

  • Develop and implement a strategic business development plan and structure
  • Identify potential pharmaceutical, biotech, diagnostic and academic partners and competitors in the target market and conduct appropriate research on the prospective partners’ and competitors’ business.
  • Assess business opportunities in detail, prepare financial business plans and bring them to approval by senior management
  • Initiate new relationships with prospective partners, while maintaining existing relationships
  • Analyze current lead- and pipeline development candidates with regard to profitability, competition and growth potential
  • Develop and negotiate contract terms and conditions with partners in close cooperation with the management
  • Collaborate with R&D team to ensure product specifications and projects are executed on-time and as agreed and develop IP and technological growth strategies
  • Plan and organize portfolio review meetings, workshops and project-related meetings

Qualifications, skills and experience

  • PhD or Master’s degree in business administration, science, engineering or related field
  • 5 or more years of professional experience in business development or portfolio management in the pharmaceutical industry
  • Expertise in identifying sources of market and competitor insights, structuring and selecting relevant information
  • Experience in identifying and defining business opportunities, structuring and presenting complex topics and moderating creative discussions
  • Excellent verbal and written communication skills – must be able to communicate clearly within the organization and externally with authorities, partners and investors
  • Fluent in written and spoken German and English

 

We offer:

  • Excellent and flexible working conditions
  • Versatile position with a high rate of self-responsibility
  • Working in an interdisciplinary, highly motivated and experienced team
  • Salary above average pay scale
  • Long-term prospective in a dynamic, aspiring company

Please send your electronic application via e-mail to office@cardior.de Your information and documents will be treated strictly confidential. The purpose of this document is to describe the representative responsibilities and general level of complexity and it is not a substitute for the specific job description of the individual position.

Clinical Project Manager (CPM)

Employment Type

  • Permanent
  • Full time 100%

Duties and Responsibilities

  • Planning, preparation and coordination of clinical development studies (Phase I and II) in alignment with the CMO.
  • Management, communication, and oversight of clinical CROs and other relevant development partners on a national and international level.
  • Support preparation and maintenance of clinical study documents.
  • Budget and time-line planning and support controlling.
  • Support and interaction with Quality Assurance and handling of SOP documents in clinical trials.
  • Contribution to innovative research projects.

Qualifications, Skills and Experience

  • Completed PhD in-life sciences, medicine or pharmacy.
  • At least 4 years of experience in clinical project management for phase I and/or II studies
  • Good knowledge of applicable guidelines, guidances, regulatory framework for clinical development, as well as an understanding of relevant Pharmacovigilance activities.
  • Excellent self-organization skills and team driven spirit.
  • Excellent communication skills in German and English (both written and spoken).
  • Goal orientation and ability to comprehend, structure and oversee and complex clinical development projects.
  • Professional knowledge of common software packages (MS Project, Word, PowerPoint, Excel) as well as clinical development tools and databases.

Additional Desirable Qualifications

  • Track record of successfully performed clinical trials, preferably in early phases for cardiac indications.
  • Experience in Risk based QM in clinical trials.

 

We offer

  • Excellent working conditions in a modern Biotech-lab
  • Versatile duties and responsibilities
  • Working in a highly motivated and experienced team
  • Salary above average pay scale
  • Long-term prospective in a dynamic, aspiring company

 

Please send your electronic application via e-mail to office@cardior.de. Your information and documents will be treated strictly confidential. The purpose of this document is to describe the representative responsibilities and general level of complexity and it is not a substitute for the specific job description of the individual position. Cardior does not accept unsolicited resumes and inquiries from 3rd party recruitment agencies.

Cardior Pharmaceuticals GmbH/ Feodor-Lynen-Str. 15/ 30625 Hannover/ Germany

www.cardior.de

Intellectual Property (IP) Manager

Employment Type

  • Permanent
  • Full or part-time 75-100%

Duties and Responsibilities

  • Develop and oversee the company’s intellectual property strategy in compliance with the management.
  • Managing communications with, and directing the activities of, outside counsel; actively assist in preparing, filing, (and prosecuting domestic and foreign) patent applications, including preparing arguments in response to office actions in compliance with the scientific personnel.
  • Work with R&D to assess patentability of new inventions; assist in drafting and reviewing related invention disclosures.
  • Negotiate and monitor license agreements, negotiate and execute confidentiality agreements.
  • Oversee and communicate adherence to application timelines.
  • Prepare confidential and non -confidential disclosures and descriptions of intellectual property and related information for potential investors.
  • Review, approve and budget IP expenditure.
  • Develop and coordinate workshops and periodic trainings to company employees regarding intellectual property and commercialization.

Qualifications, Skills and Experience

  • Master’s degree in science, business, engineering or related field.
  • at least 3 years of working experience in managing the preparation and prosecution of patent applications.
  • Experience in conducting patentability and freedom-to-operate searches.
  • Ability to develop strategic plans necessary to provide a strong IP position for the Company’s products.
  • Excellent oral and written communication skills – must be able to communicate clearly both within the organization and externally with authorities, partners and investors.
  • fluent in written and spoken German and English.

Additional Desirable Qualifications

  • Advocacy skills in connection with patent prosecution.
  • Legal training, qualifications and/or experience especially in relation to IP rights, copyright, patents, trademarks and designs.
  • Working experience in technology transfer and/or commercializing technology.

 

We offer

  • Excellent and flexible working conditions.
  • Versatile duties and responsibilities.
  • Working in a highly motivated and experienced team.
  • Salary above average pay scale.
  • Long-term prospective in a dynamic, aspiring company.

 

 

Please send your electronic application via e-mail to office@cardior.de Your information and documents will be treated strictly confidential. The purpose of this document is to describe the representative responsibilities and general level of complexity and it is not a substitute for the specific job description of the individual position. Cardior does not accept unsolicited resumes and inquiries from 3rd party recruitment agencies.

 

Cardior Pharmaceuticals GmbH/ Feodor-Lynen-Str. 15/ 30625 Hannover/ Germany

www.cardior.de

We are seeking an experienced

 

Research Scientist

 

in the fields of cardiovascular biology and pharmacology. We offer the opportunity to join our research team for the preclinical development of novel ncRNA based therapeutics. The research area will be interdisciplinary, covering areas of cell biology, pharmacology, toxicology with focus on oligonucleotide drug development.

 

Employment Type

  • Full time position
  • The position is initially funded for 2 years, with potential for extension

Duties and Responsibilities

  • Planning, design, execution and documentation of cell biology and pharmacology experiments for preclinical evaluation of ncRNA based drug candidates
  • Characterization of in vitro activity of drug candidates in models of heart failure by using genetic, molecular, biochemical, functional and imaging methods
  • Provide support for in vivo efficacy studies
  • Summarize results and present findings at company level and at scientific meetings
  • Prepare lab documentations, protocols and reports
  • Publish results in top-tier journals

Qualifications, Skills and Experience

  • Academic degree (PhD preferred) in cell biology, pharmacology or cardiovascular areas
  • Expertise in the area of cardiovascular disease, non-coding RNAs and drug development
  • 1-3 years of relevant working experience preferably in GLP-environment
  • Detailed knowledge and hands on experience of modern molecular biology techniques, in particular, nucleic acid purification and RNA analytical techniques
  • Must be fluent in written and spoken German and English
  • Being a team player with strong motivation and interpersonal skills, and ability to work independently

Additional Desirable Qualifications

  • training, qualifications and/or relevant experience in drug development area
  • Industry experience is a plus

 

We offer

  • Excellent and flexible working conditions
  • Versatile duties and responsibilities
  • Working in a highly motivated and experienced team
  • Publishing in high ranking journals
  • Participation in scientific meetings
  • Salary above average academic pay scale
  • Long-term prospective in a dynamic, aspiring company

 

Please send your electronic application via e-mail to office@cardior.de. Your information and documents will be treated strictly confidential. The purpose of this document is to describe the representative responsibilities and general level of complexity and it is not a substitute for the specific job description of the individual position. Cardior does not accept unsolicited resumes and inquiries from 3rd party recruitment agencies.

 

Cardior Pharmaceuticals GmbH/ Feodor-Lynen-Str. 15/ 30625 Hannover/ Germany

www.cardior.de

 

We are seeking an experienced 

Biological Laboratory Assistant /Technician (BTA) or MTA, CTA

in the fields of cardiovascular biology and pharmacology. We offer the opportunity to join our research team for the preclinical development of novel ncRNA based therapeutics. The research area will be interdisciplinary, covering areas of cell biology, pharmacology, toxicology with focus on oligonucleotide drug development.

 

 

Employment Type

  • Full time position.
  • The position is initially funded for 2 years, with potential for extension.

Duties and Responsibilities

  • Contribution to innovative research projects.
  • Conduct of molecular biology and cell culture experiments for preclinical evaluation of non-coding RNA based drug candidates.
  • Document (in English) experiments according to industry standards.
  • Taking care of general laboratory organization tasks.

Qualifications, Skills and Experience

  • Biological laboratory assistant/technician qualifications (e.g. MTA, BTA, CTA) with at least 2 years of working experience in academia/industry.
  • Enhanced knowledge and hands on experience of modern molecular biology techniques, in particular, nucleic acid purification and RNA analytical techniques is desired.
  • Willingness to work with biological tissue and body fluid samples.
  • Knowledge in standard computer programs (MS Office).
  • Ability to work efficiently in a team and interest in working self-organized and independently.
  • Good written and verbal communication skills in English and German.

Additional Desirable Qualifications

  • Training, qualifications and/or experience especially in RNA analytics (RNA isolation, cDNA synthesis, qRT-PCR, etc.).
  • Industry experience is a plus.

 

We offer

  • Excellent working conditions in a modern Biotech-lab.
  • Versatile duties and responsibilities.
  • Working in a highly motivated and experienced team.
  • Salary above average pay scale.
  • Long-term prospective in a dynamic, aspiring company.

 

 

Please send your electronic application via e-mail to Barbara Gärtner-Rupprecht at office@cardior.de. Your information and documents will be treated strictly confidential. The purpose of this document is to describe the representative responsibilities and general level of complexity and it is not a substitute for the specific job description of the individual position. Cardior does not accept unsolicited resumes and inquiries from 3rd party recruitment agencies.

 

Cardior Pharmaceuticals GmbH/ Feodor-Lynen-Str. 15/ 30625 Hannover/ Germany
www.cardior.de

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